Scientists find new drug target to treat coronavirus, fight future pandemic

The idea behind the future drug would be that it works early in the infection.
Share If You Like The Article

The latest study, published in the journal Science Signaling, provides critical information that could aid drug development against future coronaviruses as well as SARS-CoV-2.

The idea behind the future drug would be that it works early in the infection.
The idea behind the future drug would be that it works early in the infection.

WASHINGTON: Scientists have identified a novel target for a drug that can treat the SARS-CoV-2 virus, which causes COVID-19, and also help tackle a future coronavirus pandemic.

The researchers at Northwestern University Feinberg School of Medicine in the US noted that scientists should prepare for a possible next coronavirus pandemic.

“God forbid we need this, but we will be ready,” said Karla Satchell, professor of microbiology-immunology at Feinberg School of Medicine.

The team previously mapped the structure of a virus protein called nsp16, which is present in all coronaviruses.

The latest study, published in the journal Science Signaling, provides critical information that could aid drug development against future coronaviruses as well as SARS-CoV-2.

“There is great need for new approaches to drug discovery to combat the SARS-CoV-2/COVID-19 pandemic and infections from future coronaviruses,” Satchell said.

The idea behind the future drug would be that it works early in the infection.

“If somebody around you gets the coronavirus, you would run to the drugstore to get your medication and take it for three or four days.

If you were sick, you wouldn’t get as sick,” Satchell explained.

The researchers mapped three new protein structures in three-dimensional views and discovered a secret identifier in the machinery that helps the virus hide from the immune system.

They found a coronavirus-specific pocket in the protein, nsp16, that binds the virus-genomic fragment held in place by a metal ion.

The fragment is used by the coronavirus as the template for all the viral building blocks.

There is potential to make a drug to fit this unique pocket that would block function of this protein from the coronavirus, the researchers said.

It would not block the function of a similar protein from human cells that lacks the pocket, they said, adding such a drug would only target the invader protein.

Nsp16 is considered one of the key viral proteins that could be inhibited by drugs to stop the virus shortly after a person gets exposed.

The goal, researchers said, is to stop the virus early before people get too sick.

The team worked to generate key information about this protein and is collaborating with chemists who will use the information to design drugs against the protein.

The researchers noted that while some of the coronavirus proteins vary a lot, nsp16 is nearly the same across most of them.

The unique pocket discovered by the team is present in all the different coronavirus members.

This means that drugs designed to fit this pocket should work against all coronaviruses, including a virus that emerges in the future, according to the researchers.

It should also work against the common cold that is caused by a coronavirus, they said.

The researchers envision any drug developed based on the team’s finding of the coronavirus pocket would be part of a treatment cocktail taken by patients early in the course of the disease.

That could include drugs similar to Remdesivir, that prevents the virus from producing the template for the building blocks that is necessary for it to replicate itself, they added.


Share If You Like The Article

196 thoughts on “Scientists find new drug target to treat coronavirus, fight future pandemic

  1. купить путевку в янгантау кисловодск санаторий смена отзывы по социальной путевке
    санаторий заря кисловодск отзывы отдыхающих 2021 год база отдыха в подмосковье с детьми душ шарко цена
    омск хостелы отдых в сочах все включено сосновая горка г зима

  2. отель европейский аксай официальный новый афон жилье у моря
    бутик отель три богатыря муром санатории евпатория орджоникидзе кисловодск
    вятичи ул мира 17 кременки солнечногорск гостиницы отель мартон пашковский краснодар

  3. вилла аннигора отели сестрорецка
    отели в лондоне цены гостиницы ленинградской области отели челябинска недорого
    гостиница западный краснодар турбазы уфа домики санатории в центре кисловодска

  4. сочи отель альмира отдых в витязево с питанием
    гостиничный комплекс олимп дивеево отель броско на новом арбате отзывы о санатории машук акватерм железноводск
    силиври турция гостиница жемчужина у моря санаторий зеленая роща сочи

  5. гамма отель ольгинка официальный сайт белые ночи сочи санаторий контакты
    хостел ester house москва отель тропикана брехово карелия путевки цены
    гастроэнтеролог сочи отзывы бфо пятигорск официальный сайт сочи радуга фнс

  6. гостиница роза ветров рыбачье ливадия санаторий казань официальный сайт
    велий отель москва моховая река бешенка отдых в сочи 2021 санатории и пансионаты
    санаторий ингала в заводоуковске цена путевки отдохнуть в подмосковье на выходные гостиница евразия южно сахалинск

  7. кедровая роща кабардинка колпашево гостиницы
    отель старинная анапа официальный санаторий утес алушта отзывы турбазы самарской области цены на 2021 недорого
    кодинск гостиницы краснодарский край анапа гостевой дом дельта севастополь

  8. невинномысск гостиница кубань bronza hotel санкт петербург
    джемете крым пансионат голубой залив коктебель официальный гостиница митинская 52
    сон у моря мисхор официальный сайт отель ибис москва ленинградский проспект 37 казань санаторий

  9. карасан санаторий стоимость такси от аэропорта адлер до лоо
    отель беларусь гостиница званка волхов славянка анапа карта
    санаторий в самарской области 519 автобус отели в ласпи крым

  10. таганрог спа отель терскол отдых
    черноморец санаторий крым гостевые дома в форосе крым 2021 отель moscow holiday
    гранд отель изобильный голицын новый свет кристофф отель санкт петербург официальный

  11. гостиница город киржач туры на новый 2022
    золотой линкор гостевой дом евпатория теплый бассейн в крыму фотини анапа
    канака отели санаторий в зеленогорске ленинградской области цены карта кисловодска с санаториями

  12. санаторий хмельник профсоюзный хостел 515 нижний новгород
    санатории башкортостан во сколько рассвет в геленджике санатории ессентуки цены
    pontos plaza hotel ессентуки отель old estate hotel spa псков маджестик отель алеан

  13. санаторий в челябинске феодосия новый свет
    золотой пляж ялта гагры туры гостиница кубинка 8
    отель круиз в костроме ночной 18 3 мес за 600 руб белые скалы абхазия отзывы

  14. septilin strattera 40 mg prospect The car is thought to have been shunted behind from another vehicle and forced off the road to head for Mrs Cowley and her son as they crossed the entrance to a car park in Leigh in Lancashire, near their home lasix for weight loss In case of biologically confirmed premenopausal status, contraception is required while on tamoxifen treatment

  15. doxycycline 4, the author should show a little more background information about these enzymes, thymidine synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, explain the correlation between the expression of these enzymes and the cells sensitive to 5 fluorouracil

  16. However, in many of these trials, patients were randomized after having been disease free for the first 2 to 3 years of tamoxifen therapy where to get nolvadex Coronal postcontrast CT image shows right hydronephrosis solid arrow with ureteral dilatation to the level of a proximal ureteral stricture dashed arrow

Leave a Reply

Your email address will not be published. Required fields are marked *